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CiiS Lab
Johns Hopkins University
112 Hackerman Hall
3400 N. Charles Street
Baltimore, MD 21218
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Lab Director
Russell Taylor
127 Hackerman Hall
rht@jhu.edu
Last updated: May 11, 2018
The goal of this project is to evaluate the feasibility of ultrasound needle guidance for hydrogel injection during cervical cancer brachytherapy. My role focuses on developing the prototype needle and training phantom for this specific application and conducting preliminary tests on the model.
Locally advanced cervical cancer is a common presentation among unscreened women. Unlike early-stage disease, locally advanced cervical cancer has finite survival times and cannot be cured by surgery alone (with a high relapse rate at 30%). Recent data have repeatedly and consistently shown the benefit of administering brachytherapy following external beam radiotherapy (EBRT) to prolong survival and to improve patient outcomes (when coupled with chemotherapy). However, brachytherapy is a complex, challenging procedure which requires accurate, real-time tracking and contouring of the cervical tumor mass to achieve maximal tumor control while maintaining minimal radiation toxicity to surrounding nearby structures e.g. the bladder and rectum. Thus, there is a clear need to differentiate the cervical tumor mass from surrounding normal tissues e.g. the rectovaginal septum during brachytherapy.
While other imaging technologies have been investigated (e.g. intraoperative MRI and preoperative MRI/CT), they are limited in terms of practicality and cost. This is especially a challenge in resource-limited countries which often harbor the highest rates of locally advanced disease (in part due to limited screening and unavailability of vaccines). For this project, we propose the use of advanced ultrasound imaging systems in addressing this important clinical problem.
In brachytherapy planning, it is routine practice to inject a hydrogel spacer to minimize radiation dose to normal anatomical structures. However, this is a challenging procedure, and inaccurate needle placement can lead to complications such as accidental perforation of the bowel and rectum. The project involves developing an advanced ultrasound needle guidance system which is initially designed for lumbar punctures. We hypothesize that advanced ultrasound imaging techniques can be applied to needle design for reliable and accurate guidance of needle placement into the recto-vaginal septum for hydrogel injections during brachytherapy.
There are two goals for the overaching project:
1. Adapt needle for ultrasound-compatibility in guidance for hydrogel spacer injection in the recto-vaginal septum.
2. Develop an ultrasound-compatible phantom to assist training on localizing and visualizing a needle for hydrogel space injection during the preparation of a patient for brachytherapy.
My scope, in terms of this course, is primarily focused on item 2, the construction of the phantom.
The deliverables listed here are the most updated version. For original deliverables, please reference the “Project Proposal” and “Project Presentation” files in a later section.
Please see Documentation section below for links to the documentation described above.
For this project, it is possible to take advantage of the research that has already been done at the Medical UltraSound Imaging and Intervention Collaboration (MUSiiC) Lab to address a clearly defined clinical need, particularly that of ultrasound guidance. The needle manufacturing process adapts the electronic and algorithmic structure of the Active Ultrasound Pattern Injection System (AUSPIS) for use with the hydrogen injection needle. In addition, this system will be attempted with a trans-rectal ultrasound system instead of with the standard abdominal ultrasound transducers, for optimal proximity to the site of interest.
My main goal for this course, however, is the creation of an ultrasound compatible phantom that can be used to for training residents or other medical professionals in hydrogel spacer injection in a delicate area, particularly the rectovaginal septum.
Multiple iterations making different shapes and hardness of the plastisol will be done prior to putting together the phantom. These tests will allow me to gain familiarity with the phantom making process.
My approach involves the use of plastisol, a long-lasting yet soft material that can be used to replicate the texture of tissue to make the phantom more realistic to the user. For the first phantom, I use gradations in the ratio of Soft Plastic to Plastic Softener to control the degree of softness of the tissue. I use geometric shapes to simulate the relevant organs and tissue structures, such as the vaginal wall, the uterus, and the rectal wall.
In the next step, I try to replicate the echogenicity of the female pelvis tissue by applying microbeads of varying densities to the plastisol. Different microbead distributions will create different acoustic patterns under ultrasound, and good control will allow us to replicate the ultrasound quality of the phantom, improving on existing models.
Finally, I expand on this work by using 3D prints from manual volume segmentation of patient MRI (with smoothing) on the 3D Slicer software in order to generate anatomically accurate molds for the phantom as an improvement on my second prototype.
As part of the evaluation, I use an abdominal ultrasound system and spinal needle to test the performance of these phantoms under ultrasound imaging, and evaluate whether they are useful for people practicing hydrogel injection in the brachytherapy procedure.
The complete detailed review of the technical approach and results, along with informative figures and tables, is available in the pdf below titled “Final Report.”
The dependencies listed here are the most updated version. For original dependencies, please reference the “Project Proposal” and “Project Presentation” files in a later section.
The milestones and timeline listed here are the most updated version. For the original projected milestones and timeline, please reference the “Project Proposal” and “Project Presentation” files in a later section.
Here is a sample timeline. Note that in green is the work done prior to the Mid-Point presentation, while the work in red is the work done after the Mid-Point presentation up to the final presentation.
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Related recommended readings:
Bair, R. J., Bair, E., & Viswanathan, A. N. (2015). A radiopaque polymer hydrogel used as a fiducial marker in gynecologic-cancer patients receiving brachytherapy. Brachytherapy, 14(6), 876-880.
Banerjee, R., & Kamrava, M. (2014). Brachytherapy in the treatment of cervical cancer: a review. International journal of women's health, 6, 555.
Bell, M. A. L., Kuo, N. P., Song, D. Y., Kang, J. U., & Boctor, E. M. (2014). In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging. Journal of biomedical optics, 19(12), 126011.
Damato, Antonio L., Megan Kassick, and Akila N. Viswanathan. “Rectum and bladder spacing in cervical cancer brachytherapy using a novel injectable hydrogel compound.” Brachytherapy 16.5 (2017): 949-955.
Guo, X., Kang, H. J., Etienne-Cummings, R., & Boctor, E. M. (2014). Active ultrasound pattern injection system (AUSPIS) for interventional tool guidance. PloS one, 9(10), e104262.
Nattagh, Khashayar, et al. “A training phantom for ultrasound-guided needle insertion and suturing.” Brachytherapy 13.4 (2014): 413-419.
Petric, P., & Kirisits, C. (2016). Potential role of TRAns Cervical Endosonography (TRACE) in brachytherapy of cervical cancer: proof of concept. Journal of contemporary brachytherapy, 8(3), 215.
Schmid, M. P., Pötter, R., Brader, P., Kratochwil, A., Goldner, G., Kirchheiner, K., … & Kirisits, C. (2013). Feasibility of transrectal ultrasonography for assessment of cervical cancer. Strahlentherapie und Onkologie, 189(2), 123-128.
Sharma, D. N., Rath, G. K., Thulkar, S., Kumar, S., Subramani, V., & Julka, P. K. (2010). Use of transrectal ultrasound for high dose rate interstitial brachytherapy for patients of carcinoma of uterine cervix. Journal of gynecologic oncology, 21(1), 12-17.
Viswanathan, A. N., Damato, A. L., & Nguyen, P. L. (2013). Novel use of a hydrogel spacer permits reirradiation in otherwise incurable recurrent gynecologic cancers. Journal of Clinical Oncology, 31(34), e446-e447.
Zhang, H. K., Lin, M., Kim, Y., Paredes, M., Kannan, K., Patel, N., … & Boctor, E. M. (2017, March). Toward dynamic lumbar punctures guidance based on single element synthetic tracked aperture ultrasound imaging. In Medical Imaging 2017: Image-Guided Procedures, Robotic Interventions, and Modeling (Vol. 10135, p. 101350J). International Society for Optics and Photonics.
Here give list of other project files (e.g., source code) associated with the project. If these are online give a link to an appropriate external repository or to uploaded media files under this name space.2018-18
