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Osteoporotic Bone Augmentation

Our goal is to develop a software workstation to assist in performing femoral augmentation for osteoporotic patients. The surgical procedure consists of a series of bone cement injections into the femur. The bone augmentation system features preoperative biomechanical planning to determine the most advantageous cement injection site(s) and injection protocol to increase the strength of the femur. During the surgery, we will navigate the injection device and inraoperatively reconstruct virtual models of the injected cement. The injected cement models can be used to update the injection protocol intraoperatively.


This image guided percutaneous femoroplasty system can be divided into three main phases:

  1. Planning
  2. Navigation
  3. Intraoperative Evaluation

Status and Results to Date

For preoperative evaluation we conduct finite element analysis of the biomechanics of the femur from CT image sets.For intraoperative evaluation we are reconstructing 3D model of the bone cement from 2D X-ray projections. During intraoperative evaluation we optimize registration estimates with multi-image optimization

Future Plans

Project Personnel

Name Institution Affiliation
Dr. Mehran Armand Applied Physics Lab Principal Investigator
Dr. Russell Taylor Johns Hopkins University Principal Investigator
Dr. Peter Kazanzides Johns Hopkins University Principal Investigator
Dr. Yoshito Otake Johns Hopkins University Post-Doc
Michael Kuzter Johns Hopkins University Graduate student
Robert Armiger Applied Physics Lab Research Scientist
Ryan Murphy Applied Physics Lab Research Scientist
Ehsan Basafa Johns Hopkins University Graduate student
Blake Lucas Johns Hopkins University Graduate student
Ben Xin Kang University of Hong Kong Graduate student
Wen P. Liu Johns Hopkins University Graduate student



Affiliated labs


  1. X. Kang, R. H. Taylor, M. Armand, Y. Otake, W. P. Yau, P. Y. S. Cheung and Y. Hu, “Correspondenceless 3D-2D registration based on expectation conditional maximization”, Proc. SPIE 7964, 79642Z (2011). (Cum Laude Best Poster Award)
  2. Wen P. Liu, Mehran Armand, Yoshito Otake and Russell H. Taylor, “Optimization of multi-image pose recovery of fluoroscope tracking (FTRAC) fiducial in an image-guided femoroplasty system”, Proc. SPIE 7964, 79641D (2011). doi:10.1117/12.877800
  3. Otake Y, Armand M, Sadowsky O, Armiger RS, Kutzer MD, Mears SC, et al. , “An image-guided femoroplasty system: development and initial cadaver studies,” Proc. SPIE March 4, 2010 7625(1), 76250P (2010).
  4. Otake Y, Armand M, Sadowsky O, Armiger R, Kazanzides P, Taylor R. , “An Iterative Framework for Improving the Accuracy of Intraoperative Intensity-Based 2D/3D Registration for Image-Guided Orthopedic Surgery,” Lecture Notes in Computer Science 6135, 23-33 (2010).
  5. Otake Y, Armand M, Sadowsky O, Kutzer DM, Armiger RS, Basafa E, et al. , “Development of a navigation system for femoral augmentation using an intraoperatie C-arm reconstruction,” Proceedings of 9th Annual Meeting of CAOS-International, Boston, June, 177-180 (2009).
research.bone_augmentation.1300892731.txt.gz · Last modified: 2019/08/07 12:03 (external edit)